Many Mailenable users are familiar with the error " Server communication failure. Please refresh your browser and try again. ". This error shows when you try to send an email using Mailenable webmail. In today's lesson, we will learn how to fix this. In general, there are two ways to resolve this problem: STEP 1 : The Mailenable webmail is mostly compatible with 32-bit applications written in .NET 2.0. To begin with, you can try this. Just go to MailenableAppPool and in Advanced settings change the .NET version to 2.0 and 32 bit as TRUE. STEP 2 : If the .NET version is already 2.0 and the error still occurs, then follow these steps. Go to Mailenable Bin path Search for " MeInstaller.exe " file > Run it as Administrator Now Select Option 13. Set .Net Framework version for web application > Next Now it will ask for the ASP.Net configuration details and select the appropriate one you want to use > Execute Hopefully, this will fix the problem.